Robert G. Lowery is an accomplished inventor based in Belleville, Wisconsin, renowned for his significant contributions to biochemistry and molecular biology. With a portfolio of six patents, Lowery's work has paved the way for advancements in drug discovery and therapeutic applications.

Latest Patents

One of Robert G. Lowery's latest innovations is focused on genetically engineered G-alpha proteins. This invention relates to novel engineered Ga proteins along with assay methods that can significantly advance drug discovery. The engineered proteins described in his invention contain alterations of at least one, and preferably two or more, highly conserved amino acid residues among all four subfamilies of Ga proteins. A prominent engineered protein in this patent is the double mutant, Gαπ R178M A326S. This specific combination of mutations has yielded an unexpectedly amplified effect on Ga function, enhancing both GTPase activity and GDP dissociation. This synergistic effect may revolutionize the examination of GPCR signaling pathways and contribute to the development of new pharmacotherapies, especially for central nervous system disorders such as Parkinson's disease.

Additionally, Lowery has developed an assay method for group transfer reactions. This patent discloses an isolated antibody produced against a donor product from enzymatically catalyzed group transfer reactions. The antibody is noteworthy for its ability to preferentially recognize the donor-product guanosine diphosphate (GDP) in the presence of guanosine triphosphate (GTP). The invention includes immunoassays that utilize these antibodies and provides kits designed for performing these assays.

Career Highlights

Robert G. Lowery has dedicated his career to advancing the field of biochemistry through his innovative research and development work. He currently works at Bellbrook Labs, LLC, where he continues to push the boundaries of what is possible in drug discovery and molecular biology.

Collaborations

Throughout his career, Lowery has worked alongside talented colleagues, including Karen Kleman-Leyer and Matt Staeben. These collaborations have undoubtedly enriched his research and contributed to the successful outcomes of their collective projects.

Conclusion

Robert G. Lowery exemplifies the spirit of innovation through his groundbreaking work in engineering G-alpha proteins and developing novel assay methods. His contributions not only enhance our understanding of biochemical processes but also hold promise for the advancement of therapeutic strategies aimed at combating serious health conditions. As an inventor, Lowery continues to inspire future generations of scientists and innovators.

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