Company Filing History:
Years Active: 1986-1995
Title: The Innovations of Robert E Louie
Introduction
Robert E Louie is a notable inventor based in Berkeley, CA (US). He has made significant contributions to the field of immunology, particularly in the preparation of human immunoglobulin. With a total of 2 patents, his work has had a profound impact on the medical community.
Latest Patents
One of Louie's latest patents focuses on the preparation of human immunoglobulin free of hepatitis C. This patent details the effects of Cohn-Oncley cold alcohol fractionation on the infectivity of two prototype retroviruses, specifically mouse xenotropic type C and the LAV strain of AIDS retrovirus. The research indicates a significant reduction in retrovirus titer, achieving at least a 100,000-fold reduction of LAV when fractionating plasma to fraction II. Furthermore, adjustments to pH 4.0 at filtrate III were found to be as effective for viral inactivation as the precipitation of fraction II from filtrate III with 25% ethanol. Liquid immunoglobulin preparations spiked with LAV and incubated at 27 degrees Celsius for three days resulted in an additional 1,000-10,000-fold reduction of LAV titer. These findings support the clinical and epidemiological evidence that therapeutic immunoglobulin preparations processed by Cohn-Oncley cold ethanol processing do not transmit retroviruses such as the LAV strain of the AIDS virus.
Another significant patent involves high titer cytomegalovirus immune serum globulin. This patent describes a method for screening normal plasma from donors who have not been vaccinated with a cytomegalovirus vaccine for higher than normal titers of naturally occurring antibodies. The plasma with high titers can be pooled and fractionated to produce hyperimmune serum globulin, which may be treated for intravenous injection. This product is intended for patients with cytomegalovirus infection or those at risk, helping to raise serum titers of cytomegalovirus antibody.
Career Highlights
Throughout his career, Robert E Louie has worked with prominent companies such as Miles Laboratories, Inc. and Miles Inc. His innovative work has contributed to advancements in medical treatments and therapies.
Collaborations
Louie has collaborated with notable individuals in his field, including Milton B Dobkin and Gautam Mitra. These partnerships have further enhanced his research and development efforts.