Company Filing History:
Years Active: 2003
Title: The Innovations of Robert Calvin Dutcher
Introduction
Robert Calvin Dutcher is an accomplished inventor based in Raleigh, NC. He has made significant contributions to the field of nucleic acid modification through his innovative methods and kits. His work is particularly relevant in the context of enzyme activity detection, which has implications in various scientific and medical applications.
Latest Patents
Dutcher holds a patent for a "Method and kit for identification for nucleic acid modification enzymes and inhibitors thereof." This patent describes a method and kit designed to detect nucleic acid modification enzyme activity by monitoring changes in fluorescence polarization. The process involves a nucleic acid substrate that includes a template with a nucleic acid sequence annealed to a labeled oligo. A key feature of this invention is the incorporation of a nick or break located between the adjacent ends of the template and the labeled oligo. The addition of a nucleic acid modification enzyme to the substrate forms a reaction mixture, which can be further processed with a stop reagent. A test compound is then introduced to determine its effect on enzyme activity by comparing the resulting fluorescence polarization signal to a standard signal.
Career Highlights
Dutcher is currently employed at Syngenta Participations AG, where he continues to advance his research and development efforts. His work at Syngenta allows him to collaborate with other experts in the field and contribute to innovative solutions in agricultural biotechnology.
Collaborations
Dutcher has worked alongside notable colleagues such as Michael William Bauer and Paul Bernasconi. Their collaborative efforts have further enhanced the research and development initiatives within their organization.
Conclusion
Robert Calvin Dutcher's contributions to the field of nucleic acid modification are noteworthy, particularly through his patented methods and kits. His work at Syngenta Participations AG exemplifies the impact of innovation in scientific research.