Robert C Clouse

Title: The Innovative Contributions of Robert C. Clouse

Introduction

Robert C. Clouse is a notable inventor based in Midland, MI (US). He has made significant contributions to the field of chemistry, particularly in the development of methods for producing complex chemical compounds. With a total of 5 patents to his name, Clouse has demonstrated a commitment to innovation and scientific advancement.

Latest Patents

Among his latest patents, Clouse has developed methods for producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate. One of the methods involves adding methyl isobutyl ketone to an aqueous solution containing 4-chloro-2-fluoro-3-methoxyphenyl-boronic acid, resulting in the formation of an organic phase. This organic phase is then separated from the aqueous phase. The subsequent reaction of the 4-chloro-2-fluoro-3-methoxyphenylboronic acid with methyl 4-(acetylamino)-3,6-dichloropyridine-2-carboxylate in methyl isobutyl ketone leads to the production of methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate, which is further deacetylated to yield the final product. Additionally, he has patented a process for the preparation of 1,1'-bi-2-naphthols, which involves coupling 2-naphthols in a polar acidic solvent with a catalyst and a source of oxygen.

Career Highlights

Clouse has had a distinguished career, working with prominent companies such as The Dow Chemical Company and Dow Agrosciences LLC. His work in these organizations has allowed him to apply his innovative ideas and contribute to various projects in the chemical industry.

Collaborations

Throughout his career, Clouse has collaborated with several notable individuals, including Robert G. Asperger and Jossian Oppenheimer. These collaborations have likely enriched his work and expanded the impact of his inventions.

Conclusion

Robert C. Clouse is a remarkable inventor whose contributions to chemical processes have