Company Filing History:
Years Active: 1999-2005
Title: The Innovations of Robert B Belshe
Introduction
Robert B Belshe is a prominent inventor based in St. Louis, MO (US). He has made significant contributions to the field of virology, particularly in the development of vaccines. With a total of 3 patents, his work focuses on creating innovative solutions to combat viral infections.
Latest Patents
One of his latest patents is centered around a temperature-sensitive and cold-adapted human parainfluenza virus type 2 (HPIV-2) and vaccines based on such virus. This invention relates to isolated, attenuated viral strains of HPIV-2, which are useful in live vaccine preparations. These strains exhibit a temperature-sensitive and cold-adapted phenotype that stimulates a protective immune response in an inoculated mammal without producing severe symptoms.
Another notable patent involves live attenuated vaccines based on the cp45 HPIV-3 strain. This invention is based on the correlation of two attenuating lesions of the cp45 strain to specific genetic defects in the viral genome. It has been discovered that a significant level of attenuation of cp45, which gives rise to its temperature-sensitive and cold-adapted phenotypes, is directly associated with mutations in the large (L) gene of cp45. Furthermore, a second attenuating lesion exists independent of the temperature-sensitive lesion, associated with mutations in the hemagglutinin-neuraminidase (HN) gene of cp45. This correlation enables the creation of vaccines directed at other wild-type HPIV-3 viruses and target viruses using genetic engineering techniques.
Career Highlights
Robert B Belshe is affiliated with Saint Louis University, where he continues to advance research in virology and vaccine development. His work has been instrumental in understanding viral mechanisms and developing effective vaccines.
Collaborations
He has collaborated with notable colleagues, including Ranjit Ray and Frances K Newman, contributing to the advancement of research in his field.
Conclusion
Robert B Belshe's innovative work in vaccine development and virology has made a significant impact on public health. His patents reflect a commitment to advancing medical science and improving vaccine efficacy.