Company Filing History:
Years Active: 2010-2011
Title: Innovations of Robert Abel
Introduction
Robert Abel is an accomplished inventor based in Davie, FL (US). He has made significant contributions to the field of biochemistry, particularly in understanding the binding affinities of ligands to proteins. With a total of 3 patents, his work has advanced the methodologies used in computational biochemistry.
Latest Patents
Abel's latest patents focus on methods of calculating differences of binding affinities between congeneric pairs of ligands by way of a displaced solvent functional. This technique exhaustively enumerates the thermodynamic properties of water molecules that solvate the active site of a protein in its apostate. The process involves sampling the configurations of the solvating water, extracting thermodynamic information, and computing relative binding affinities of congeneric compounds that bind to the protein. The subject matter includes clustering observed water configurations into regions of high water occupancy, computing average system interaction energies, and constructing a 3-dimensional hydration thermodynamics map of the protein active site.
Career Highlights
Robert Abel is affiliated with Columbia University, where he continues to contribute to research in biochemistry and computational methods. His innovative approaches have garnered attention in the scientific community, leading to advancements in the understanding of protein-ligand interactions.
Collaborations
Some of his notable coworkers include Thomas R Young and Richard A Friesner. Their collaborative efforts have further enriched the research environment and have led to significant findings in their respective fields.
Conclusion
Robert Abel's work exemplifies the intersection of innovation and scientific research. His patents and methodologies have paved the way for new insights into protein interactions, making a lasting impact in the field of biochemistry.