Location History:
- Wageningen, NL (2013 - 2014)
- Gorinchem, NL (2019 - 2024)
Company Filing History:
5 out of 170 
5 out of 33 
5 out of 81 Years Active: 2013-2024
Title: Richard Van Kranenburg: Innovator in Genetic Engineering
Introduction
Richard Van Kranenburg, an accomplished inventor based in Gorinchem, Netherlands, has significantly contributed to the field of genetic engineering. With a remarkable portfolio of 10 patents, his latest inventions demonstrate his commitment to advancing biotechnology and genetic editing techniques.
Latest Patents
Among his most recent patents, Van Kranenburg has developed novel Thermostable Cas9 nucleases. This invention involves a polynucleotide that encodes a ThermoCas9 protein, designed for the engineering of eukaryotic cells such as fungi, yeast, or algae. By integrating and expressing the ThermoCas9 endonuclease within the genome of these cells, a second expression plasmid is employed to transfect them. This plasmid includes an inducible promoter and a polynucleotide encoding a guide RNA, which collaborates with the ThermoCas9 to target specific DNA locations for cleavage. Additionally, a repair-oligo is introduced to enable homologous recombination, allowing for precise deletion or substitution of nucleotides at the desired locus. Van Kranenburg’s innovations are characterized by their ability to operate at higher temperatures, exceeding 30° C, thus paving the way for enhanced genetic modification.
Career Highlights
Richard Van Kranenburg has a diverse professional background, including significant tenures at Purac Biochem B.V. and Wageningen University. His work at these respected institutions has allowed him to sharpen his expertise and extend the reach of his innovations in genetic engineering.
Collaborations
Throughout his career, Van Kranenburg has collaborated with notable professionals such as John Van Der Oost and Elleke Fenna Bosma. These alliances have not only enriched his research but have also contributed to the advancement of genetic engineering as a whole.
Conclusion
As a notable inventor in the field of biotechnology, Richard Van Kranenburg's work with Thermostable Cas9 nucleases marks a significant advancement in genetic engineering. His inventions showcase the potential for precision in genome editing, setting a remarkable benchmark for future research and applications in genetic modifications.