Company Filing History:
12 out of 1,187 
4 out of 122 
Years Active: 1989-1998
Title: The Innovative Contributions of Richard S. Smith
Introduction
Richard S. Smith is a prominent inventor based in Del Mar, California, known for his significant contributions to the field of biotechnology. With a total of 16 patents to his name, Smith has made remarkable advancements in diagnostic methods and therapeutic applications related to lipoproteins.
Latest Patents
Among his latest patents are the APO AI polypeptides and diagnostic methods and systems for quantifying APO. This invention describes an Apo AI polypeptide capable of immunologically mimicking an Apo AI epitope. The polypeptide is useful in diagnostic methods and systems for detecting Apo AI in vascular fluid samples and for the preparation of anti-Apo AI antibodies. Additionally, the polypeptide is beneficial in therapeutic methods for increasing esterified cholesterol in human patients. Another notable patent involves DNA encoding recombinant lipoprotein antigens. This patent outlines methods and compositions for determining the level of low-density lipoproteins (LDL) in plasma. The native apoprotein B-100 (apo B-100) present in LDL particles is immunologically mimicked by a polypeptide of the invention. A preferred polypeptide is a fusion protein that simultaneously mimics native apo B-100 and native apo A-I. Improved assay systems and methods for determining HDL and LDL levels in body fluid samples are also described.
Career Highlights
Richard S. Smith has had a distinguished career, working with esteemed organizations such as The Scripps Research Institute and the Scripps Clinic and Research Foundation. His work has significantly impacted the understanding and treatment of lipid-related disorders.
Collaborations
Throughout his career, Smith has collaborated with notable colleagues, including Linda K. Curtiss and Joseph L. Witztum. These collaborations have further enhanced the quality and reach of his innovative work.
Conclusion
Richard S. Smith's contributions to biotechnology through his patents and collaborations have made a lasting impact on the field. His innovative approaches to diagnostics and therapeutics continue to influence research and development in lipoprotein-related health issues.