Richard M Thorn

Title: Richard M Thorn: Innovator in Biochemical Diagnostics

Introduction

Richard M Thorn is a notable inventor based in Milford, MA (US). He has made significant contributions to the field of biochemical diagnostics, particularly in the development of peptides and processes for purifying recombinant proteins. With a total of 2 patents, his work has had a substantial impact on immunodiagnostic tests.

Latest Patents

Richard M Thorn's latest patents include "Peptides for the diagnosis of HTLV-III antibodies, their preparation" and "Process for purifying recombinant proteins, and products thereof." The first patent focuses on certain peptide fragments of the human T-cell leukemia (lymphotropic) virus (HTLV-III) that are particularly immunoreactive to HTLV-III antibodies. These peptides can be applied to immunodiagnostic tests for the detection of antibodies to HTLV-III. The second patent relates to a process for recovering recombinant protein from refractile inclusion bodies of microorganisms. This process involves disrupting cells, recovering refractile bodies containing recombinant protein, and solubilizing these bodies with a denaturant. It also includes protecting sulfhydryl groups of recombinant proteins and converting cationic amino groups to anionic carboxylic acid through derivatization. The invention further discusses the production of solid supports coated with recombinant protein, which can be used for the detection and quantification of antibodies in body fluids.

Career Highlights

Richard M Thorn is associated with Cambridge Bioscience Corporation, where he continues to advance his research and innovations. His work has been instrumental in enhancing the accuracy and efficiency of diagnostic tests in the medical field.

Collaborations

Some of his notable coworkers include Dante J Marciani and Chung-Ho Hung. Their collaborative efforts have contributed to the success of various projects within the company.

Conclusion

Richard M Thorn's contributions to the field of biochemical diagnostics through his innovative patents and collaborations highlight his role as a significant inventor. His work continues to influence the development of diagnostic technologies that improve healthcare outcomes.