Company Filing History:
4 out of 601 
3 out of 5,463 
Years Active: 1999-2006
Title: Richard J Cristiano: Innovator in Gene Transfer Technologies
Introduction
Richard J Cristiano is a prominent inventor based in Pearland, TX (US), known for his significant contributions to the field of gene transfer technologies. With a total of 7 patents, Cristiano has made remarkable advancements that enhance the expression of transgenes, which are crucial for various applications in biotechnology and medicine.
Latest Patents
One of Cristiano's latest patents is titled "Enhanced expression of transgenes." This invention provides improved methods of gene transfer, both in vitro and in vivo. By treating neoplastic cells with a DNA-damaging agent prior to transduction with a transgene, the expression of the transgene is improved up to about three-fold compared to the expression seen without the DNA-damaging agent treatment. This effect is not dependent on the tumor cell type, the method of DNA transduction, or the type of DNA-damaging agent used. The most dramatic results are observed when transduction occurs approximately one to three days after treatment with the DNA-damaging agent.
Another notable patent is "PEI: DNA vector formulations for in vitro and in vivo gene delivery." This invention relates to the fields of nucleic acid transfection and concerns novel polycation:nucleic acid compositions, methods of preparation of such compositions, and methods of transfecting cells with these compositions.
Career Highlights
Throughout his career, Richard J Cristiano has worked with esteemed institutions such as Baylor College of Medicine and the University of Texas System. His work has significantly impacted the field of gene therapy and molecular biology, paving the way for innovative treatments and research methodologies.
Collaborations
Cristiano has collaborated with notable colleagues, including Louis C Smith and Stephen Gottchalk. These partnerships have further enriched his research and contributed to the advancement of gene transfer technologies.
Conclusion
Richard J Cristiano's innovative work in gene transfer technologies has led to significant advancements in the field, as evidenced by his patents and collaborations. His contributions continue to influence research and applications in biotechnology and medicine.