This inventor holds 6 USPTO granted patents and 1 published patent application and 1 EPO patent. Top assignees: St. Jude Children's Research Hospital, Leland Stanford Junior University, Mayo Foundation for Medical Education and Research. Active years: 1996-2024.
Location History:
- Memphis, TN (US) (1996 - 2002)
- Rochester, MN (US) (2008 - 2024)
Company Filing History:
4 out of 281 
1 out of 5,497 
1 out of 1,805 
Years Active: 1996-2024
Title: The Innovative Contributions of Richard J Bram
Introduction
Richard J Bram is a notable inventor based in Rochester, MN (US), recognized for his significant contributions to the field of biomedical research. With a total of 6 patents, his work primarily focuses on advancements in medical treatments and understanding cellular mechanisms.
Latest Patents
Among his latest patents, Bram has developed PIKfyve inhibitors, which provide a compound of Formula (I) or a pharmaceutically acceptable salt thereof. This invention includes methods for treating diseases such as cancer. Another significant patent involves a lymphocyte surface receptor that binds CAML, detailing a novel lymphocyte receptor protein and its role in the calcium activation pathway. This receptor can specifically regulate B cell responses without affecting mature T cell activity, which is particularly advantageous in managing immune responses during infections or autoimmune conditions.
Career Highlights
Bram has had a distinguished career, working with prestigious institutions such as St. Jude Children's Research Hospital and Leland Stanford Junior University. His research has contributed to a deeper understanding of immune responses and potential therapeutic applications.
Collaborations
Throughout his career, Richard J Bram has collaborated with esteemed colleagues, including Gotz Von Bulow and Gerald R Crabtree. These collaborations have further enriched his research and innovations in the field.
Conclusion
Richard J Bram's innovative work and patents have made a significant impact in biomedical research, particularly in understanding immune mechanisms and developing treatments for serious diseases. His contributions continue to influence the field and inspire future research endeavors.