Company Filing History:
Years Active: 1995-1998
Title: Richard D Abramson: Innovator in Thermostable DNA Polymerases
Introduction
Richard D Abramson is a notable inventor based in Oakland, CA (US). He has made significant contributions to the field of molecular biology, particularly in the development of thermostable DNA polymerases. With a total of 5 patents, his work has advanced the understanding and application of these essential enzymes in various biotechnological processes.
Latest Patents
Among his latest patents, one focuses on "5' to 3' exonuclease mutations of thermostable DNA polymerases." This invention relates to thermostable DNA polymerases that exhibit varying levels of 5' to 3' exonuclease activity compared to their native counterparts. The patent details how specific conserved amino acid domains in these polymerases can be mutated or deleted to modify their exonuclease activity. Another significant patent is for a "DNA encoding thermostable nucleic acid polymerase enzyme from Thermus." This invention describes a purified thermostable enzyme derived from the eubacterium Thermus species Z05, which possesses DNA polymerase and reverse transcriptase activities, along with optional 5' to 3' exonuclease activity.
Career Highlights
Richard D Abramson has worked with prominent companies in the biotechnology sector, including Hoffmann-La Roche Inc. and Roche Molecular Systems, Inc. His experience in these organizations has allowed him to contribute to groundbreaking research and development in the field of DNA polymerases.
Collaborations
Throughout his career, Abramson has collaborated with esteemed colleagues such as David H Gelfand and I Lawrence Greenfield. These partnerships have further enriched his research and innovation efforts.
Conclusion
Richard D Abramson's contributions to the field of molecular biology, particularly through his patents on thermostable DNA polymerases, have had a lasting impact on biotechnology. His work continues to influence research and applications in genetic engineering and molecular diagnostics.