Rich H Griffey

Title: Rich H Griffey: Innovator in Oligonucleotide Synthesis

Introduction

Rich H Griffey is a notable inventor based in Vista, CA (US). He has made significant contributions to the field of oligonucleotide synthesis, holding a total of 4 patents. His work focuses on the development of modified pyrimidine nucleosides, which have important applications in biotechnology and pharmaceuticals.

Latest Patents

Griffey's latest patents include a process for the synthesis of 2′-O-substituted pyrimidines and oligomeric compounds derived from them. These patents disclose oligonucleotide analogs that contain pyrimidine monomeric sub-units modified at the 2′ and 5′ positions. The monomeric sub-units can undergo further modifications at the 2′ position. The improved processes for synthesizing 2′-O-substituted pyrimidine nucleosides involve the alkylation of a 2,2′-anhydropyrimidine nucleoside or a 2S,2′-anhydropyrimidine nucleoside with a weak nucleophile in the presence of a Lewis acid.

Career Highlights

Rich H Griffey is currently associated with Isis Pharmaceuticals, Inc., where he continues to innovate in the field of nucleic acid chemistry. His work has been instrumental in advancing the understanding and application of modified nucleosides.

Collaborations

Throughout his career, Griffey has collaborated with esteemed colleagues such as Phillip Dan Cook and Yogesh S Sanghvi. These collaborations have further enriched his research and contributed to the success of his inventions.

Conclusion

Rich H Griffey stands out as a prominent inventor in the realm of oligonucleotide synthesis, with a focus on innovative processes that enhance the functionality of nucleosides. His contributions continue to impact the field significantly.