Company Filing History:
Years Active: 2007-2015
Title: The Innovative Contributions of Rene Everardus Maria Toes
Introduction
Rene Everardus Maria Toes is a prominent inventor based in Leiden, Netherlands. He has made significant contributions to the field of immunology, particularly in the development of peptides that enhance immune responses against viral infections. With a total of 2 patents, his work is paving the way for advancements in vaccination and treatment strategies.
Latest Patents
Toes' latest patents focus on long peptides of 22-45 amino acid residues that induce and enhance antigen-specific immune responses. These inventions are particularly concerned with epitopes derived from the human papilloma virus (HPV). The patents detail peptides that comprise minimal T cell epitopes, providing clinically relevant approaches for immunizing subjects against (Myco)bacterially and/or virally infected cells or tumor cells, especially against HPV. The inventions demonstrate that peptide sequences of 22-35 amino acid residues can induce both peptide-specific CD8+ cytolytic cells and CD4+ T-helper cells. Furthermore, vaccination with these longer peptides results in a more vigorous CD8+ cytolytic T-cell response compared to shorter peptides. The inventions also address the challenges posed by certain minimal CTL epitopes that can tolerize cytolytic cells, offering solutions through the use of 22-35 amino acid long peptides. Additionally, these patents provide methods and uses suited for treating subjects suffering from progressive lesions and cervical cancer.
Career Highlights
Rene Toes is affiliated with Academisch Ziekenhuis Leiden, where he continues to contribute to research and innovation in immunology. His work has garnered attention for its potential impact on public health, particularly in the fight against HPV-related diseases.
Collaborations
Toes collaborates with notable colleagues such as Sjoerd Hendrikus Van Der Burg and Annemieke Geluk, who share his commitment to advancing immunological research.
Conclusion
Rene Everardus Maria Toes is a key figure in the field of immunology, with innovative patents that enhance our understanding of immune responses. His contributions are vital for developing effective treatments against viral infections and cancer.