Rena Angilena Sowell Robinson

Title: Rena Angilena Sowell Robinson: Innovator in Proteomic Biomarkers

Introduction

Rena Angilena Sowell Robinson is a distinguished inventor based in Pittsburgh, PA (US). She has made significant contributions to the field of proteomics, particularly in identifying biomarkers for sepsis in patients of varying ages. With a total of three patents to her name, Robinson's work is pivotal in advancing medical diagnostics.

Latest Patents

Robinson's latest patents focus on the development of proteomic expression platforms aimed at identifying age-related sepsis risks. One of her notable patents involves a study on young patients with intra-abdominal infections. This patent describes a semi-quantitative plasma proteomics workflow that utilizes tandem immunoaffinity depletion, iTRAQ labeling, strong cation exchange fractionation, and nanoflow-liquid chromatography coupled with high-resolution mass spectrometry. The findings reveal a protein profile that exhibits statistically significant differences in expression levels among patients with severe sepsis based on age. Key pathways identified include acute phase response, coagulation signaling, atherosclerosis signaling, lipid metabolism, and the production of nitric oxide/reactive oxygen species.

Another patent addresses proteomic biomarkers of sepsis in elderly patients, employing a similar methodology to identify age-related risks. This work underscores the importance of understanding how age influences the expression of proteins in sepsis, thereby enhancing diagnostic capabilities.

Career Highlights

Rena Angilena Sowell Robinson is affiliated with the University of Pittsburgh, where she continues her research and innovation in the field of proteomics. Her academic and professional journey reflects a commitment to improving patient outcomes through scientific discovery.

Collaborations

Robinson has collaborated with esteemed colleagues, including John A. Kellum and Zhiyun Cao, further enriching her research endeavors and expanding the impact of her work in the scientific community.

Conclusion

Rena Angilena Sowell Robinson's contributions to the field of proteomics, particularly in the context of sepsis, highlight her role as an innovative inventor. Her patents not only advance scientific understanding but also pave the way for improved diagnostic methods in medicine.