This inventor holds 1 USPTO granted patent. Top assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services. Active years: 2010.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2010
Title: Innovations by Regina G Ziegler
Introduction
Regina G Ziegler is a notable inventor based in Bethesda, MD (US). She has made significant contributions to the field of mass spectroscopy and chromatography, particularly in the detection and separation of carbonyl-containing compounds.
Latest Patents
Ziegler holds a patent titled "Methods for separation and detection of ketosteroids and other carbonyl-containing compounds." This patent discloses methods for enhancing detection by mass spectroscopy (MS) and improving chromatographic separability of carbonyl-containing compounds, such as steroids. The invention involves the reaction of a carbonyl compound with a sulfonhydrazide compound, resulting in a sulfonhydrazone that exhibits enhanced ionization efficiency during the electrospray ionization process. A specific embodiment of the patent details the derivatization of catechol estrogens with p-toluenesulfonhydrazide, which enhances detection by atmospheric pressure ionization-MS (API-MS) and separation by liquid chromatography under reverse phase conditions. Additionally, the sulfonhydrazone can be further reacted with a sulfonyl halide under alkaline conditions to derivatize hydroxyl groups in the compound.
Career Highlights
Regina G Ziegler is affiliated with the National Institutes of Health, a component of the US Department of Health & Human Services. Her work at this prestigious institution has allowed her to focus on innovative research that has practical applications in the medical and scientific communities.
Collaborations
Ziegler has collaborated with notable colleagues, including Xia Xu and David J Waterhouse, contributing to advancements in her field through teamwork and shared expertise.
Conclusion
Regina G Ziegler's innovative work in the detection and separation of carbonyl-containing compounds has made a significant impact in the field of mass spectroscopy and chromatography. Her contributions continue to influence research and applications in various scientific domains.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile