Rebecca W Muddiman

Title: The Innovative Contributions of Rebecca W. Muddiman

Introduction

Rebecca W. Muddiman is a prominent inventor based in Indianapolis, IN, known for her significant contributions to the field of electrochemical biosensors. With a total of four patents to her name, she has made remarkable advancements in diagnostic technologies that enhance the detection of analytes in biological samples.

Latest Patents

One of her latest patents is the "Electrochemical enzyme assay," which is a diagnostic kit, method, and apparatus designed for electrochemically determining the presence or concentration of an analyte in a sample. This innovative method involves forming a mixture that includes the sample, an enzyme acceptor polypeptide, an enzyme donor polypeptide, and a labeled substrate. The enzyme donor polypeptide combines with the enzyme acceptor polypeptide to create an active enzyme complex, which responds to the analyte's presence or concentration in the fluid sample. The active enzyme hydrolyzes the labeled substrate, generating an electroactive label that can be oxidized at the surface of an electrode. The resulting current from the oxidation of the electroactive compound can be measured and correlated to the analyte's concentration in the sample.

Another notable patent is for a "Reagent including an osmium-containing redox mediator." This patent introduces a new group of Os(II) and Os(III) compounds that serve as redox mediators in electrochemical biosensors. These compounds exhibit low oxidation potential, fast reaction kinetics between the electroactive center of an enzyme and the compound, slow oxidation of osmium by oxygen, and excellent solubility in aqueous medium. These mediators are particularly beneficial as components of reagents used in electrochemical biosensors for measuring analytes from biological fluids, such as blood.

Career Highlights

Rebecca has worked with esteemed companies such as Boehringer Mannheim GmbH and Roche Diagnostics GmbH, where she has honed her skills and contributed to groundbreaking research in the field of diagnostics. Her work has had a lasting impact on the development of innovative technologies that improve healthcare outcomes.

Collaborations

Throughout her career, Rebecca has collaborated with notable professionals, including Robert J. McEnroe and Zhi David Deng. These collaborations have further enriched her research and development efforts, leading to advancements in electrochemical biosensing technologies.

Conclusion

Rebecca W. Muddiman's innovative