Company Filing History:
Years Active: 2016-2020
Title: Innovations in Molecular Delivery: The Work of Raphael Labruere
Introduction
Raphael Labruere, an accomplished inventor based in Créteil, France, has made significant contributions to the field of molecular delivery systems. With a total of two patents to his name, Labruere focuses on the development of innovative technologies that have the potential to enhance the efficacy and safety of drug delivery.
Latest Patents
Among his latest innovations is a groundbreaking patent involving poly(vinyl benzoate) nanoparticles. This invention comprises nanoparticle suspensions that serve as molecular carriers, formed through the nanoprecipitation of poly(vinyl benzoate) in water with the aid of Pluronic F68 as a surfactant. These nanoparticles possess spherical structures, measuring approximately 200-250 nm in diameter, exhibiting stability in both phosphate buffer and blood serum, while also demonstrating a slow degradation rate in the presence of esterases. Laboratory kinetics experiments reveal that 78% of the coumarin-6 is effectively encapsulated within the nanoparticle's polymer matrix, with only 22% being surface-bound and quickly released. Importantly, these nanoparticles have shown non-toxicity in vitro towards human epithelial cells and bovine aortic endothelial cells. Additionally, they exhibit non-observable bactericidal activity against selected test microbes, showcasing their potential for use as carriers for lipophilic small molecules, including pharmaceutical drugs and imaging agents.
Career Highlights
Raphael Labruere currently holds a position at the University of South Florida, where he continues to drive innovation in molecular delivery systems. His research focuses on the practical applications of his inventions, aiming to address critical challenges in the pharmaceutical field and improve patient outcomes.
Collaborations
Throughout his career, Labruere has collaborated with notable researchers, including Edward Turos and Ryan Scott Cormier. These partnerships have enhanced his ability to refine his inventions and bring them closer to practical application in medical and pharmaceutical settings.
Conclusion
Raphael Labruere exemplifies the innovative spirit of inventors dedicated to advancing technology in the medical field. His work with poly(vinyl benzoate) nanoparticles highlights the potential for new molecular delivery systems that could revolutionize the way pharmaceuticals are administered. As he continues to develop and refine his inventions, Labruere remains an essential figure in the ongoing pursuit of improved healthcare solutions.