Randall W Holt

Title: Innovations in MRI Technology by Randall W. Holt

Introduction

Randall W. Holt is an accomplished inventor based in Cleveland, OH (US). He has made significant contributions to the field of medical imaging, particularly in magnetic resonance imaging (MRI). His innovative work focuses on improving the measurement of liver iron concentration, which is crucial for diagnosing various medical conditions.

Latest Patents

Randall W. Holt holds a patent for an MRI method for high liver iron measurement using magnetic susceptibility. This patent describes a process where a subject, such as a human patient, is positioned with a region of interest, like the liver, in close proximity to a phantom. A volume image is collected through the liver, the phantom, and adjacent portions of the subject using a magnetic resonance scanner. The phase component of the magnetic resonance data is reconstructed into a three-dimensional phase map. An actually measured field map is determined from the phase map, and a geometric model of the volumes occupied by the liver, the phantom, and adjacent portions of the subject is mathematically defined. A calculation routine estimates the distortions to the magnetic field in the phantom caused by the model. This fitting procedure is iteratively repeated until a susceptibility is determined for the region of interest, which predicts the actually measured field map. This susceptibility is proportional to iron concentration.

Career Highlights

Randall W. Holt is associated with the Edison Biotechnology Center, where he continues to advance his research and innovations in medical imaging technology. His work has the potential to significantly impact the diagnosis and treatment of liver-related health issues.

Collaborations

Randall has collaborated with notable colleagues, including Pedro J. Diaz and Errol M. Bellon. Their combined expertise contributes to the advancement of research in the field of biotechnology and medical imaging.

Conclusion

Randall W. Holt's innovative contributions to MRI technology demonstrate his commitment to improving medical diagnostics. His patent for measuring liver iron concentration showcases the importance of advancements in medical imaging.