Randall D Little

Title: Innovations and Contributions of Randall D. Little in Genetic Research

Introduction

Randall D. Little, based in Newtonville, MA, is a notable inventor in the field of genetics, particularly focusing on respiratory diseases and obesity. With a remarkable total of 13 patents, his work has significantly contributed to advancements in biomedical research and therapeutic development.

Latest Patents

One of Randall's latest innovations includes a patent related to nucleotide and amino acid sequences linked to respiratory diseases such as asthma. This invention encompasses genes identified from human chromosome 12q23-qter, which are associated with various conditions. It details the nucleotide sequences of these genes, isolated nucleic acids, and the polypeptides or peptides encoded by them. The patent also covers vectors and host cells containing these nucleotide sequences, as well as antibodies that specifically bind to the encoded polypeptides. Additionally, the invention discusses ligands that modulate the activity of the disclosed genes or gene products, along with methods and compositions for diagnostics and therapeutics for asthma and related diseases.

Similarly, another significant patent involves isolated nucleic acids comprising genes from human chromosome 12q23-qter and the proteins those genes encode. This innovation outlines expression vectors and host cells that harbor these genes, as well as antibodies targeting the proteins produced by these nucleic acids.

Career Highlights

Throughout his career, Randall D. Little has made notable strides in the pharmaceutical industry. He has played key roles in companies such as Oscient Pharmaceuticals Corporation and Genome Therapeutics Corporation. His work in these organizations has propelled research in genetic therapies and advanced the understanding of disease mechanisms.

Collaborations

Randall has collaborated with esteemed colleagues, including Tim Keith and Paul Van Eerdewegh. These partnerships have fostered a conducive environment for interdisciplinary research and innovation in genetics, enhancing the potential for impactful discoveries.

Conclusion

Randall D. Little’s contributions to genetic research are evidenced by his extensive patent portfolio, which continues to influence the fields of diagnostics and therapeutics for diseases such as asthma and obesity. His collaborative efforts and professional experiences have established him as a key figure in the advancement of biomedical innovations.