Ram Aiyar

Title: Ram Aiyar: Innovator in Oncolytic Virus Therapy

Introduction

Ram Aiyar is a notable inventor based in Rockville, MD (US). He has made significant contributions to the field of cancer therapy through his innovative work on oncolytic viruses. His research focuses on developing therapeutic methods that harness the immune system to combat various types of cancer.

Latest Patents

Ram Aiyar holds a patent for "Exogenous tap inhibitor armed oncolytic viruses and therapeutic uses thereof." This invention relates to exogenous TAP inhibitor armed oncolytic viruses that selectively replicate in cancer cells. These viruses are designed to evade CD8+ cytolytic T-cells and induce the immune system to recognize tumor cells. The preferred viruses include a heterologous gene that encodes a function affecting antigen presentation by inhibiting TAP. Additionally, the viruses may comprise one or more heterologous genes encoding immunomodulatory polypeptides, prodrug converting enzymes, or matrix degrading enzymes. The patent also covers compositions and therapeutic methods for treating various cancers, including melanoma, head and neck cancer, ovarian cancer, breast cancer, glioblastoma, bladder cancer, prostate cancer, lung cancer, liver cancer, colorectal cancer, pancreatic cancer, and renal cancer.

Career Highlights

Ram Aiyar is currently associated with Benevir Biopharm, Inc., where he continues to advance his research in oncolytic virus therapy. His work is pivotal in developing innovative treatments that could potentially improve cancer patient outcomes.

Collaborations

Some of his notable coworkers include Matthew C Mulvey and Steven R Fuhrmann. Their collaborative efforts contribute to the ongoing research and development in the field of oncolytic viruses.

Conclusion

Ram Aiyar's innovative work in the realm of oncolytic viruses represents a significant advancement in cancer therapy. His contributions have the potential to change the landscape of cancer treatment and improve the lives of many patients.