This inventor holds 3 USPTO granted patents. Top assignees: Targeted Genetics Corporation, The University of Texas System, University of Pittsburgh. Active years: 1998-2004.
Company Filing History:
2 out of 20 
1 out of 5,630 
1 out of 1,959 
Years Active: 1998-2004
Title: Ralph Wilfred Paul: Innovator in Gene Therapy and Drug Delivery Systems
Introduction
Ralph Wilfred Paul is a notable inventor based in Seattle, WA, with a focus on advancements in gene therapy and drug delivery systems. He holds three patents that reflect his innovative contributions to the field of biotechnology. His work has significant implications for cancer treatment and therapeutic delivery methods.
Latest Patents
One of Ralph Wilfred Paul's latest patents is for the Mini-E1A gene and gene products. This invention provides methods and compositions for the suppression of oncogenic transformation, tumorigenesis, and metastasis. It discloses functional domains of E1A responsible for the suppression of transformation and offers mini-E1A constructs that can be utilized for tumor suppression. Additionally, the invention outlines methods for the novel use of mini-E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors. Another significant patent involves stable lipid-comprising drug delivery complexes and methods for their production. This patent describes novel, stable, concentrated, biologically active, and ready-to-use lipid-comprising drug delivery complexes. The biological activity of these complexes is comparable to prior art formulations, and upon purification, they are found to be 50 to 500 times more concentrated than those formed by admixture. This method allows for large-scale production of lipid-comprising drug delivery systems that are useful for gene therapy and other applications.
Career Highlights
Ralph Wilfred Paul has had a distinguished career, working with prominent organizations such as Targeted Genetics Corporation and the University of Pittsburgh. His experience in these institutions has allowed him to contribute significantly to the field of biotechnology and drug delivery systems.
Collaborations
Throughout his career, Ralph has collaborated with notable individuals, including Aaron Garth Loomis and Leaf Huang. These collaborations have further enhanced his research and development efforts in the biotechnology sector.
Conclusion
Ralph Wilfred Paul is a pioneering inventor whose work in gene therapy and drug delivery systems has the potential to transform cancer treatment. His patents reflect a commitment to innovation and a desire to improve therapeutic outcomes for patients.