Location History:
- Jacksonville, FL (US) (1977 - 1978)
- W. Jacksonville, FL (US) (1978)
Company Filing History:
Years Active: 1977-1978
Title: Ralph E Close: Innovator in Synthesis of Vitamin E and Acetylenic Compounds
Introduction
Ralph E Close is a notable inventor based in Jacksonville, FL, who has made significant contributions to the field of chemistry. He holds a total of seven patents, showcasing his innovative approach to the synthesis of various chemical compounds, particularly those related to Vitamin E.
Latest Patents
Among his latest patents, Ralph E Close has developed a process for the synthesis of esters of acetylenic alcohols, which is crucial for creating perfume products. This process involves a coupling reaction that begins with forming a C.sub.15 acetylene from hexahydropseudoionone. The acetylene is then coupled with 1-acetoxy-4-chloro-3-methylbut-2-ene to produce a C.sub.20 acetoxy-enyne. This compound can undergo partial hydrogenation and saponification to yield dehydrophytol, an important intermediate in the synthesis of Vitamin E and other valuable products. Additionally, he has patented a method for synthesizing acetylenic compounds useful in preparing dehydrophytols. This process involves replacing the hydroxyl group of an acetylenic carbinol with a halogen to create a propargylic halide, which is then dehalogenated to form an allene and isomerized to the desired acetylene. This invention is particularly beneficial for the synthesis of Vitamin E.
Career Highlights
Ralph E Close has established a successful career at SCM Corporation, where he has been able to apply his expertise in chemical synthesis. His work has not only advanced the field but has also contributed to the development of essential products in the market.
Collaborations
Throughout his career, Ralph has collaborated with notable colleagues such as William Oroshnik and John M Derfer. These partnerships have fostered innovation and have led to the successful development of various chemical processes.
Conclusion
Ralph E Close is a distinguished inventor whose work in the synthesis of Vitamin E and acetylenic compounds has made a significant impact in the field of chemistry. His innovative processes continue to influence the industry and contribute to advancements in chemical synthesis.