Rajesh Gottimukkala

Title: Innovations by Rajesh Gottimukkala

Introduction

Rajesh Gottimukkala is a prominent inventor based in Fremont, California. He has made significant contributions to the field of molecular biology, particularly in the detection of gene fusions. With a total of four patents to his name, his work has advanced the methodologies used in genetic research and diagnostics.

Latest Patents

Rajesh's latest patents include innovative methods for partner agnostic gene fusion detection. This method involves amplifying a nucleic acid sample using a primer pool to produce multiple amplicons. The primers target various exon-exon junctions of a driver gene, allowing for the sequencing and alignment of the amplicons to a reference sequence. The process normalizes the read counts and applies baseline corrections to determine predicted breakpoints for gene fusions without prior knowledge of specific fusion partners.

Another notable patent focuses on the detection of fusions using compressed molecular tagged nucleic acid. This method compresses nucleic acid sequence data by associating each sequence read with a molecular tag sequence. It determines consensus sequence reads and alignments, generating a compressed data structure that aids in detecting fusions effectively.

Career Highlights

Rajesh Gottimukkala is currently employed at Life Technologies Corporation, where he continues to innovate in the field of genetic research. His work has been instrumental in developing advanced techniques that enhance the accuracy and efficiency of gene fusion detection.

Collaborations

Throughout his career, Rajesh has collaborated with notable colleagues, including Jeoffrey Schageman and Fiona Hyland. These collaborations have contributed to the successful development and implementation of his patented methodologies.

Conclusion

Rajesh Gottimukkala's contributions to the field of molecular biology through his innovative patents have significantly impacted genetic research. His work continues to pave the way for advancements in gene fusion detection and diagnostics.