Company Filing History:
Years Active: 2019-2020
Title: Raja Chinnappan: Innovator in DNA Aptamer Technology
Introduction
Raja Chinnappan, an accomplished inventor based in Riyadh, Saudi Arabia, has made significant contributions to the field of biochemistry through his innovative work on DNA aptamers. With two patents to his name, his research focuses on applications that enhance drug monitoring and diagnostics.
Latest Patents
Chinnappan's latest patents include "Full-length and truncated anti-coagulant Dabigatran etexilate specific DNA aptamers for electrochemical and fluorescence sensing applications." This patent outlines the development of long and short aptamer sequences that demonstrate high affinity and specificity for analyzing the drug Dabigatran etexilate. These aptamers play a crucial role in therapeutic drug monitoring, pharmacokinetic studies, and naturalization processes. Through a rigorous selection method involving a randomized 60-mer DNA library, several specific aptamer sequences were successfully identified. The evaluation of binding affinity and specificity showed dissociation constants (k) ranging from 47 to 312 nM, with minimal cross-reactivity to other analytes. Additionally, the use of fluorophore-labeled complimentary sequences allowed for the mapping of the binding region within the aptamer, emphasizing their potential in diagnostics.
Another important patent is "Electrochemical screening for the selection of DNA aptamers." In this work, he describes a novel method for selecting DNA aptamers against 11-deoxycortisol (11-DCL) using a gold electrode for target immobilization. This method enhances the traditional SELEX process by using the gold electrode as a solid matrix. The process allows for the direct measurement of bound DNA through square wave voltammetry, providing a streamlined approach to aptamer selection.
Career Highlights
Raja Chinnappan presently works at Alfaisal University, where he leverages his expertise in biochemistry to drive innovative research forward. His academic and professional journey has been marked by a commitment to advancing the potential applications of DNA technology in medical diagnostics.
Collaborations
In his professional endeavors, Chinnappan has collaborated with notable researchers such as Mohammed Zourob and Shimaa Eissa, contributing to a dynamic and innovative research environment that fosters significant advances in the field.
Conclusion
Raja Chinnappan stands out as a leading inventor in the realm of DNA aptamer technology. His groundbreaking patents not only pave the way for improved drug monitoring and diagnostics but also underscore the importance of collaboration in scientific research. As the potential clinical applications of his work continue to unfold, Chinnappan's contributions will undoubtedly have a lasting impact on the field.