Company Filing History:
Years Active: 2002-2003
Title: Innovations by Raja C Mugasimangalam: A Trailblazer in cDNA Technology
Introduction
Raja C Mugasimangalam, based in Bengaluru, India, is an accomplished inventor with a prominent focus on advancements in cDNA technology. With two patents to his name, Raja has made significant contributions to the field of molecular biology, specifically in the methods of gene sorting and cDNA normalization.
Latest Patents
Raja's latest patents showcase his expertise and innovative spirit. The first patent, titled "Sequence specific and sequence non-specific methods and materials for cDNA normalization and subtraction," provides a comprehensive approach to constructing a normalized cDNA library. This invention not only facilitates the construction of low copy gene libraries but also includes preparations for probes derived from biological samples, along with a kit designed for normalized cDNA library construction.
The second patent, "Sequence-dependent gene sorting techniques," presents a systematic method for sorting genes. This novel approach encompasses five key steps: (1) preparing double-stranded cDNA (ds cDNA) molecules from mRNA, (2) digesting these ds cDNA molecules, (3) ligating dsDNA oligonucleotide adaptors to the digested cDNA, (4) amplifying the ligated cDNA molecules, and (5) sorting the amplified cDNA into non-overlapping groups. Raja's invention further extends to methods for creating sub-libraries of ligation sets, reflecting his thorough understanding of genetic material manipulation.
Career Highlights
Raja currently works with Quark Biotech, Inc., where he leverages his innovative skills to bridge the gap between science and practical applications in biotechnology. His role involves not only inventing new technologies but also refining existing methodologies to enhance research outcomes in the field of genetics.
Collaborations
Throughout his career, Raja has had the opportunity to collaborate with talented individuals, including coworkers Levy Ulanovsky and Paz Einat. These collaborations have enabled him to combine diverse expertise and perspectives, further enriching his inventions and contributions to the scientific community.
Conclusion
Raja C Mugasimangalam's inventive spirit and dedication to advancing cDNA technology make him a significant figure in the field of molecular biology. Through his patents and collaborative efforts, Raja continues to impact research methodologies and applications, paving the way for future innovations in gene sorting and library construction.