Raffaella Squilloni

Title: Raffaella Squilloni: Innovator in Circular RNA Technologies

Introduction

Raffaella Squilloni is a prominent inventor based in Cambridge, MA (US). She has made significant contributions to the field of RNA technology, particularly in the development of circular RNA compositions and methods. With a total of 2 patents, her work is paving the way for advancements in genetic engineering and therapeutic applications.

Latest Patents

Raffaella's latest patents focus on circular RNA compositions and methods. These patents describe innovative circular RNA that includes group I intron fragments, spacers, an IRES, duplex forming regions, and an expression sequence. Notably, the expression sequence encodes a chimeric antigen receptor (CAR). The circular RNA developed by Raffaella demonstrates improved expression, functional stability, immunogenicity, ease of manufacturing, and half-life compared to linear RNA. Additionally, her inventive methods and constructs enhance circularization efficiency, splicing efficiency, and purity when compared to existing RNA circularization approaches.

Career Highlights

Throughout her career, Raffaella has worked with notable organizations such as Orna Therapeutics, Inc. and the Massachusetts Institute of Technology. Her experience in these institutions has allowed her to collaborate with leading experts in the field and contribute to groundbreaking research.

Collaborations

Raffaella has collaborated with esteemed colleagues, including Robert Alexander Wesselhoeft and Daniel Griffith Anderson. These partnerships have further enriched her research and innovation in RNA technologies.

Conclusion

Raffaella Squilloni is a trailblazer in the field of circular RNA, with her patents and collaborations significantly impacting genetic research and therapeutic development. Her work continues to inspire advancements in RNA technology and its applications.