Rae Sung Chang

Title: The Innovative Mind of Rae Sung Chang: Advancements in Drug Delivery Systems

Introduction

Rae Sung Chang, an accomplished inventor based in Ann Arbor, MI, has made significant strides in the field of biomedicine with her innovative approaches to drug delivery systems. With a portfolio of three patents, Chang is focused on improving therapeutic techniques that enhance patient outcomes and reduce the complexities associated with traditional drug administration methods.

Latest Patents

Chang's latest patents demonstrate her commitment to innovation in healthcare. One of her notable inventions is a patent for coated implants designed for long-term controlled release of antibody therapeutics. This technology involves implants for anti-VEGF therapy that maintain stability and facilitate the controlled release of bevacizumab and other sensitive polypeptides while preserving the stability of proteins in micronized powder form. Her devices achieve near zero-order kinetics and complete release of over 80%, utilizing cylindrical implants that are suitable for intravitreal injection.

Another remarkable patent involves an efficient aqueous encapsulation and controlled release system with a porous, self-healing biodegradable polymer matrix. This design features an ionic charged biopolymer along with a pH modifying species strategically placed within the pores. The integration of oppositely charged ionic macromolecules forms a nonsoluble polyelectrolyte complex, where the careful selection of biopolymer molecular weight, self-healing polymer matrix properties, and pore forming agents work synergistically for optimal macromolecule binding and controlled release.

Career Highlights

Rae Sung Chang is affiliated with the University of Michigan, where she contributes her expertise to advance research in medical applications. Her inventions reflect a deep understanding of the challenges within the pharmaceutical industry, leading her to develop practical solutions for better drug delivery methods.

Collaborations

Throughout her career, Chang has collaborated with prominent colleagues such as Steven Paul Schwendeman and Ronak B Shah, who share her vision of innovating within the biomedical field. Their combined efforts are focused on enhancing the efficacy of drug therapies and ensuring patient safety through groundbreaking technology.

Conclusion

Rae Sung Chang exemplifies the innovative spirit, with her inventions contributing valuable advancements in drug delivery systems. With a focus on improving therapeutic efficacy and patient outcomes, her work at the University of Michigan continues to inspire future innovations in medicine. As an inventor, her legacy will undoubtedly make a lasting impact on the field of biomedical engineering.