Company Filing History:
2 out of 850 
1 out of 1,179 
Years Active: 2017-2023
Title: Rachael L Brake: Innovator in Gastrointestinal Treatments
Introduction
Rachael L Brake is a prominent inventor based in Natick, MA (US), known for her significant contributions to the field of immunology and oncology. With a total of three patents to her name, she has made remarkable strides in developing methods to treat gastrointestinal immune-related adverse events associated with immune oncology treatments.
Latest Patents
One of her latest patents focuses on methods of treating gastrointestinal immune-related adverse events in immune oncology treatments. This invention provides methods to reduce gastrointestinal immune-related adverse events, such as colitis and diarrhea, in subjects undergoing immune treatments, including anti-CTLA4 antibody and anti-PD-1 antibody combination treatments for melanoma. The methods involve administering a therapeutically effective amount of a polypeptide that inhibits MAdCAM-integrin binding, such as an anti-α4β7 integrin antibody, including vedolizumab or a related antibody. Another notable patent relates to pharmaceutical formulations of a pan-RAF kinase inhibitor and processes for their preparation. This invention encompasses a pharmaceutical composition comprising Compound 1 or a pharmaceutically acceptable salt thereof for cancer treatment, along with a process for its preparation.
Career Highlights
Rachael has worked with notable companies in the pharmaceutical industry, including Millennium Pharmaceuticals Limited and Takeda Pharmaceutical Company Limited. Her experience in these organizations has contributed to her expertise in developing innovative treatments.
Collaborations
Throughout her career, Rachael has collaborated with esteemed colleagues, including Huifeng Niu and Eric H Westin. These collaborations have further enhanced her research and development efforts in the field.
Conclusion
Rachael L Brake is a distinguished inventor whose work in gastrointestinal treatments has the potential to significantly impact patient care in oncology. Her innovative patents and collaborations reflect her commitment to advancing medical science.