Company Filing History:
Years Active: 1980-1982
Title: R Murray Ratcliffe: Innovator in Glycoscience
Introduction
R Murray Ratcliffe is a notable inventor based in Edmonton, Canada. He has made significant contributions to the field of glycoscience, particularly in the synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides. With a total of three patents to his name, Ratcliffe's work has implications in both medical and biochemical applications.
Latest Patents
His latest patents focus on the synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from O-acetylated glycals. These compounds react with ceric ammonium nitrate in the presence of sodium azide to yield O-acetylated 2-azido-2-deoxy glycosyl nitrates. These nitrates can be utilized to prepare 2-amino-2-deoxy sugars, such as D-galactosamine and lactosamine. Furthermore, the O-acetylated 2-azido-2-deoxy glycosyl nitrates can be converted into O-acetylated 2-azido-2-deoxy glycosyl halides. This process is essential for the preparation of O-acetylated 2-azido-2-deoxy glycosides, which can subsequently be reduced to 2-amino-2-deoxy glycosides. Notably, the synthesis of these glycosides corresponds to the terminal units of the antigenic determinant for the human A blood group. The attachment of these glycosides to a solid support results in immunoabsorbents that efficiently absorb anti-A antibodies from blood plasma.
Career Highlights
R Murray Ratcliffe has established himself as a key figure in his field through his innovative research and development. His work has not only advanced scientific understanding but has also paved the way for practical applications in immunology and biochemistry.
Collaborations
He has collaborated with notable figures in the field, including Raymond U Lemieux, enhancing the impact of his research through shared expertise and knowledge.
Conclusion
R Murray Ratcliffe's contributions to glycoscience through his patents and collaborations highlight his role as an influential inventor. His work continues to have a significant impact on the field, particularly in