Location History:
- Lutz, FL (US) (2008 - 2013)
- Largo, FL (US) (2017)
Company Filing History:
4 out of 1,933 
1 out of 894 
1 out of 3 Years Active: 2008-2017
Title: R Douglas Shytle: Innovator in Lithium Therapeutics
Introduction
R Douglas Shytle is a notable inventor based in Lutz, Florida, recognized for his contributions to the field of neuropsychiatric treatments. He holds 4 patents that focus on the innovative use of lithium salts in therapeutic applications. His work aims to enhance the efficacy and safety of lithium-based treatments for mania and other neuropsychiatric disorders.
Latest Patents
Shytle's latest patents include compositions of lithium salts and methods of use. Lithium is widely regarded as the gold standard for treating mania, but it has a narrow therapeutic window that poses challenges. Recent research has explored new chemical entities that could replicate lithium's therapeutic effects. Shytle's work emphasizes the re-engineering of lithium therapeutics through cocrystallization. His evaluations of pharmacokinetics reveal that previously unexplored lithium salts, such as lithium salicylate and lithium lactate, exhibit significantly different pharmacokinetics compared to the commonly used lithium carbonate. Notably, lithium salicylate has shown to maintain elevated blood and brain levels of lithium for over 48 hours post-dose, without the sharp peaks that contribute to toxicity issues associated with current lithium therapies.
Career Highlights
Throughout his career, Shytle has worked with esteemed institutions, including the University of South Florida and the United States Government as represented by the Department of Veterans Affairs. His research has significantly advanced the understanding of lithium's pharmacokinetics and its potential for improved therapeutic applications.
Collaborations
Shytle has collaborated with notable colleagues, including Cyndy Davis Sanberg and Paul R Sanberg. Their combined expertise has contributed to the innovative research and development of lithium therapeutics.
Conclusion
R Douglas Shytle's work in the field of lithium therapeutics represents a significant advancement in the treatment of neuropsychiatric diseases. His innovative approach to re-engineering lithium salts holds promise for improving patient outcomes and addressing the limitations of current therapies.