Company Filing History:
Years Active: 2003
Title: Quang Qu: Innovator in Recombinant Adeno-Associated Virus Production
Introduction
Quang Qu is a notable inventor based in Alameda, CA. He has made significant contributions to the field of biotechnology, particularly in the production and purification of recombinant adeno-associated virus (rAAV). His innovative methods have the potential to advance gene therapy applications.
Latest Patents
Quang Qu holds a patent for "Large-scale recombinant adeno-associated virus (rAAV) production and purification." This patent outlines methods for large-scale purification of rAAV virions produced without infectious adenovirus. The rAAV is generated in a host cell line through triple-transfection with an accessory function vector, an AAV vector, and an AAV helper vector. The purification process involves preparing a lysate from the host cell line and utilizing various combinations of ion exchange chromatography media and affinity chromatography media. The affinity chromatography medium may include an AAV receptor or an antibody with binding affinity for AAV, such as heparin sulfate. The invention also contemplates the use of various cation exchange and anion exchange media, with optional purification steps like filtering the lysate or treating it with a nuclease.
Career Highlights
Quang Qu is currently associated with Avigen, Inc., where he continues to work on innovative solutions in the field of gene therapy. His expertise in rAAV production and purification has positioned him as a key player in advancing therapeutic technologies.
Collaborations
Quang collaborates with John Fraser Wright, leveraging their combined expertise to enhance the development of biotechnological innovations.
Conclusion
Quang Qu's contributions to the field of recombinant adeno-associated virus production and purification exemplify the impact of innovative thinking in biotechnology. His work not only advances scientific understanding but also holds promise for future therapeutic applications.