Company Filing History:
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1 out of 1 Years Active: 2014
Title: Qiongming Liu: Innovator in Transcription Factor Research
Introduction
Qiongming Liu is a prominent inventor based in Beijing, China. He has made significant contributions to the field of molecular biology, particularly in the study of transcription factors. His innovative methods have advanced the understanding of gene expression regulation.
Latest Patents
Qiongming Liu holds a patent titled "Method for enrichment and isolation of endogenous transcription factor and complexes thereof and corresponding tandem arrays of concatenated transcription factor response elements." This invention provides a method for the enrichment and isolation of endogenous transcription factors and their complexes. The method utilizes the property of transcription factors binding to sequence-specific DNA elements during the regulation of gene expression. The corresponding tandem arrays of concatenated transcription factor response elements (catTFRE) are designed and synthesized as dual copies of DNA response elements for various transcription factors. The synthesized catTFRE is cloned into a target vector, and biotinylated catTFRE with 200 bp arms is prepared using a PCR strategy. For the enrichment and isolation of endogenous transcription factors and their complexes, the biotinylated catTFRE is immobilized to streptavidin-coated magnetic beads and incubated with nuclear extract. This allows for the isolation of endogenous transcription factors and their complexes from the nuclear extract, with further identification possible through mass spectrometry or other functional characterization methods.
Career Highlights
Throughout his career, Qiongming Liu has worked with esteemed institutions such as Baylor College of Medicine and the Institute of Radiation Medicine at the China Academy of Military Medical Sciences. His work has been instrumental in advancing research in transcription factors and their roles in gene regulation.
Collaborations
Qiongming Liu has collaborated with notable colleagues, including Jun Qin and Chen Ding. Their combined expertise has contributed to the success of various research projects and innovations in the field.
Conclusion
Qiongming Liu's contributions to the field of transcription factor research have paved the way for new methodologies in gene expression studies. His innovative patent and collaborations highlight his commitment to advancing scientific knowledge.