Location History:
- Plymouth, MN (US) (2008)
- Brooklyn Park, MN (US) (2010 - 2014)
Company Filing History:
3 out of 8,734 
1 out of 2,464 
Years Active: 2008-2014
Title: Innovations of Qingshan (Sam) Ye in Heparin Determination Systems
Introduction
Qingshan (Sam) Ye is an accomplished inventor based in Brooklyn Park, MN (US). He has made significant contributions to the field of medical technology, particularly in the development of systems for determining heparin concentration in blood. With a total of 3 patents to his name, his work has the potential to enhance patient care in clinical settings.
Latest Patents
One of his latest patents is a point of care heparin determination system. This invention describes methods and devices for the point of care determination of heparin concentration in blood. The system includes cartridges that feature protamine ion sensitive electrodes (ISEs) and reference electrodes. These cartridges are designed to automatically determine heparin concentration. Some systems add blood to a protamine bolus sufficient to bind all heparin, leaving excess protamine. The concentration of excess protamine can be determined by measuring the initial slope of the electrode potential rate of change and comparing it to known protamine concentration slope values. Additionally, some cartridges utilize an oscillating pressure source to move the blood-protamine mixture back and forth across the protamine ISE. The system may also employ a second blood sample with the heparin removed or degraded to create a blank reference sample. Protamine ISEs can include materials such as polyurethane polymer, DNNS ionophore, and NPOE plasticizer, with specific structural characteristics to enhance their functionality.
Career Highlights
Qingshan (Sam) Ye has worked with notable companies in the medical field, including Medtronic, Inc. and Warsaw Orthopedic, Inc. His experience in these organizations has contributed to his expertise in medical device innovation and development.
Collaborations
Throughout his career, Qingshan has collaborated with talented individuals such as Wei Qin and Daniel Cheek. These partnerships have likely fostered a creative environment that encourages innovation and the advancement of medical technologies.
Conclusion
Qingshan (Sam) Ye's contributions to the field of heparin determination systems exemplify the impact of innovative thinking in medical technology. His patents and career achievements highlight the importance of advancements in patient care and clinical diagnostics.