Pui Shi Pang

Title: Innovations by Pui Shi Pang - Advancing Cancer Treatment through Amino Acid Depletion Therapy

Introduction

Pui Shi Pang is a notable inventor based in Hong Kong, China, recognized for his significant contributions to the field of medical therapies aimed at combating cancer. His innovative approaches focus on the development of specialized compositions and methods that enhance the efficacy of cancer treatment.

Latest Patents

Pui Shi Pang holds a patent entitled "Compositions and methods for amino acid depletion therapy." This patent encompasses sophisticated compositions and methodologies for preparing high-purity arginase, alongside high-efficiency preparation methods of monosubstituted polyethylene glycol conjugation of arginase. The primary goal of his invention is to utilize arginase in combination with asparaginase to effectively inhibit cancer cell proliferation. His advanced technique includes an initial high-temperature precipitation step followed by ion exchange, resulting in arginase with a purity of 90% or greater. The innovative process for conjugation utilizes maleimide-derivatized polyethylene glycol at controlled conditions, enhancing the utility of arginase in treatment regimens, particularly targeting cancer cells with low endogenous asparaginase expression.

Career Highlights

Pui Shi Pang is affiliated with Avalon Polytom (HK) Limited, where he continues to push the boundaries of cancer treatment innovations. His work exemplifies the intersection of biotechnology and therapeutic development.

Collaborations

Throughout his career, Pui Shi Pang has collaborated with esteemed colleagues, including Johnson Yiu-Nam Lau and Yun Chung Leung. Together, they foster an environment of innovation and research that aims to create impactful solutions to difficult medical challenges.

Conclusion

Pui Shi Pang's contributions to the field of amino acid depletion therapy represent a promising avenue for enhancing cancer treatment methodologies. His patent highlights the potential of arginase in combination therapies, demonstrating an innovative approach to treating cancer more effectively. The collaborative efforts with his coworkers further underline the importance of teamwork in advancing medical science.