Company Filing History:
Years Active: 1991-1997
Title: Inventor Prudimar S. Segui: A Pioneer in Chimeric Receptor Proteins
Introduction
Prudimar S. Segui is a distinguished inventor based in San Diego, California, known for his groundbreaking contributions to the field of molecular biology and receptor proteins. With a total of six patents to his name, he has made significant strides in understanding and manipulating hormone receptors to advance scientific knowledge and potential therapeutic applications.
Latest Patents
Prudimar S. Segui's latest patents include innovations concerning chimeric steroid hormone superfamily receptor proteins. One notable invention features a novel retinoic acid receptor that is encoded by cDNA carried on plasmid phRAR1, which has been deposited with the American Type Culture Collection for patent purposes. This invention also encompasses various chimeric receptor proteins constructed by exchanging functional domains between key hormones such as glucocorticoids, mineralocorticoids, and retinoic acid receptors. Additionally, he disclosed a novel method for identifying functional ligands for receptor proteins, utilizing the interchangeable nature of functional domains. This method enables the creation of hybrid receptors that can be activated by new ligands, showcasing retinoic acid as a specific ligand for the novel receptor.
Career Highlights
Segui is currently associated with the Salk Institute for Biological Studies, a premier research institution known for its contributions to biological science. His work at this institute has been pivotal in advancing the understanding of hormone receptor mechanisms and their application in various fields. His innovative approaches and discoveries have opened new avenues for research, particularly in areas related to endocrine signaling and pharmacology.
Collaborations
Throughout his career, Prudimar S. Segui has collaborated with notable scientists including Ronald Mark Evans and Estelita S. Ong. These collaborations have enhanced the depth of research and innovation within the field, fostering an environment of knowledge sharing and scientific advancement.
Conclusion
Prudimar S. Segui stands out as a significant inventor in the realm of receptor biology. His innovative patents and collaborations underscore his commitment to advancing scientific research. As he continues to build upon his work at the Salk Institute for Biological Studies, the potential impacts of his discoveries promise to contribute immensely to the future of therapeutics and molecular biology.