Praveen K Shukla

Title: The Innovative Mind of Praveen K Shukla

Introduction

Praveen K Shukla, based in Burlington, MA, is a notable inventor recognized for his significant contributions to nucleic acid chemistry. With a portfolio that includes two patents, he focuses on advancing the field through innovative technologies and methodologies.

Latest Patents

Praveen's latest patents revolve around the development of dithiolane functionalized nucleoside amidites and supports aimed at enhancing the immobilization of biomolecules on solid surfaces. His first patent describes novel 1,2-dithiolane functionalized nucleoside phosphoramidites and corresponding solid supports. This invention allows for oligonucleotide chain extension utilizing standard DNA and RNA synthesis chemistry, resulting in high-quality oligonucleotides. Moreover, these nucleosides are designed with a primary hydroxyl for DMTr (4,4'-dimethoxytrityl) function, enabling effective chain elongation under typical conditions.

The second patent focuses on a dithiolane-based thiol modifier for the labeling and stronger immobilization of biomolecules. The thiol modified oligonucleotides developed under this patent are resilient against unfavorable conditions such as high temperatures and saline environments. The dithiolane phosphoramidites derivative features multiple thiol groups, granting it versatility for incorporation at various positions within oligonucleotides, thus enhancing their function in research and application.

Career Highlights

Throughout his illustrious career, Praveen has collaborated with reputable companies including Chemgenes Corporation. His work has contributed to innovations that significantly impact the realm of nucleic acid chemistry. His patents are a testament to his inventive spirit, translating complex scientific concepts into practical applications.

Collaborations

Praveen has worked alongside esteemed colleagues such as Suresh C Srivastava and Santhosh Kumar Thatikonda. Their collaboration has fostered an environment of innovation and advancement in their shared field.

Conclusion

Praveen K Shukla's contributions to nucleic acid chemistry through his patents illustrate his passion for innovation and invention. His advancements not only improve the synthesis of oligonucleotides but also provide essential tools for future research in various scientific domains. As a dedicated inventor, Praveen continues to shape the landscape of biochemical research and application with his groundbreaking work.