Company Filing History:
Years Active: 2003-2009
Title: Ponnampalam Gopalakrishnakone: Innovator in Therapeutic Peptides
Introduction
Ponnampalam Gopalakrishnakone is a distinguished inventor based in Singapore, known for his significant contributions to the field of therapeutic peptides. He holds a total of 5 patents that focus on innovative methods and compositions for the treatment of various inflammatory diseases, including arthritis and cancer.
Latest Patents
One of his latest patents involves the development of a new 18-residue homodimerized peptide, designated PIP [59-67] dimer. This peptide is a mutant of the optimized anti-inflammatory peptide P-NT.II, which has shown potential in modulating both the inflammatory and bone-damaging components of rheumatoid arthritis. The invention utilizes solid-phase chemistry to design variants of P-NT.II, which were tested for their inhibitory activity against secretory phospholipase A2 (sPLA2) and matrix metalloproteinases (MMPs). Among the tested mutants, the dimerized peptide emerged as the most potent inhibitor against sPLA2 and human recombinant MMP-1. This invention highlights the utility of the peptide analogue PIP [59-67] dimer as a potential therapeutic agent for inflammatory diseases and cancer.
Career Highlights
Ponnampalam Gopalakrishnakone is affiliated with the National University of Singapore, where he conducts research and develops innovative solutions in the field of biomedicine. His work has significantly advanced the understanding of phospholipase inhibitors and their applications in treating inflammatory conditions.
Collaborations
He has collaborated with notable colleagues, including Maung-Maung Thwin and Kandiah Jeyaseelan, to further enhance the research and development of therapeutic agents.
Conclusion
Ponnampalam Gopalakrishnakone's innovative work in therapeutic peptides has the potential to transform the treatment landscape for inflammatory diseases and cancer. His contributions continue to inspire advancements in biomedical research and therapeutic development.