Ping Gong

Title: Innovations of Ping Gong in Electrochemical Detection

Introduction

Ping Gong is an accomplished inventor based in Elmhurst, NY (US), known for his significant contributions to the field of electrochemical detection. He holds three patents that showcase his innovative approaches to biomolecular detection and analysis.

Latest Patents

One of his latest patents is the "Active CMOS sensor array for electrochemical biomolecular detection." This invention eliminates the need for bulky optical instruments traditionally required in fluorescence-based sensing assays. By integrating sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates, Gong has miniaturized the sensing platform, enhancing portability for point-of-care applications. This technology enables high-throughput and highly-parallel analysis, featuring a four-by-four active sensor array for multiplexed electrochemical biomolecular detection. The integrated potentiostats, control amplifiers, and dual-slope ADCs stimulate the electrochemical cell and detect the current flowing through on-chip gold electrodes at each sensor site, resulting from biomolecular reactions occurring on the chip surface. The patent also describes post-processing techniques for fabricating biologically-compatible surface-electrode arrays in CMOS that can withstand harsh electrochemical environments.

Another notable patent is "Capacitive morpholino diagnostics for analysis of nucleic acids." This invention utilizes Morpholinos, a class of uncharged DNA analogues, for surface-hybridization applications. Monolayers of Morpholino probes on gold supports are fabricated using methods similar to those employed with DNA, allowing for efficient and sequence-specific hybridization with target strands. The hybridization-induced changes in interfacial charge organization are analyzed with electrochemical methods, revealing insights into the molecular mechanisms connecting surface hybridization state to interfacial capacitance.

Career Highlights

Throughout his career, Ping Gong has made significant strides in the field of electrochemical sensing. His work has led to advancements that enhance the capabilities of biomolecular detection, making it more efficient and accessible.

Collaborations

Gong has collaborated with notable individuals in his field, including Kenneth Shepard and Rastislav Levicky. These collaborations have contributed to the development and refinement of his innovative technologies.

Conclusion

Ping Gong's contributions to electrochemical detection through his patents and collaborations highlight his role as a leading inventor in the field. His work continues to pave the way for advancements in biomolecular analysis and detection technologies.