Ping-Chuan Tsai

Title: Innovations of Ping-Chuan Tsai in Protein Engineering

Introduction

Ping-Chuan Tsai is a notable inventor based in Fremont, CA, who has made significant contributions to the field of protein engineering. With a total of 4 patents to his name, Tsai's work focuses on the development of novel fusion proteins that enhance protein-protein interactions.

Latest Patents

One of Tsai's latest patents is titled "Fusion proteins comprising an engineered knottin peptide and uses thereof." This patent presents a general approach to engineering existing protein-protein interactions through domain addition and evolution. The disclosure teaches the creation of novel fusion proteins that include knottin peptides, where a portion of the knottin peptide is replaced with a sequence designed for binding to a specific target. These fusion proteins can be bispecific or multispecific, allowing them to bind to and/or inhibit two or more receptors or receptor ligands. Additionally, knottins may be fused with an existing ligand or receptor to increase the affinity of a ligand-receptor interaction or to create a multispecific protein. The fusion proteins may also comprise a knottin peptide fused to another protein, which facilitates proper expression and folding of the knottin.

Career Highlights

Ping-Chuan Tsai is affiliated with Leland Stanford Junior University, where he continues to advance his research in protein engineering. His innovative work has garnered attention in the scientific community, contributing to the understanding and application of fusion proteins in various biotechnological fields.

Collaborations

Tsai has collaborated with notable colleagues, including Jennifer R. Cochran and Douglas Scott Jones, further enhancing the impact of his research through teamwork and shared expertise.

Conclusion

Ping-Chuan Tsai's contributions to the field of protein engineering, particularly through his innovative patents, highlight his role as a leading inventor in this area. His work continues to influence advancements in biotechnology and protein interactions.