Pia Hydén

Title: Pia Hyden: Innovator in Recombinant Aryl Sulfatase Production

Introduction

Pia Hyden is a notable inventor based in Stocksund, Sweden. She has made significant contributions to the field of biotechnology, particularly in the production and purification of recombinant arylsulfatase A. With a total of 4 patents, her work has implications for treating conditions related to the nervous system.

Latest Patents

Hyden's latest patents focus on the production and purification of recombinant arylsulfatase A. The first patent describes a process for producing recombinant arylsulfatase A in a cell culture system. This process involves culturing a mammalian cell capable of producing rASA in a liquid medium within a system comprising one or more bio-reactors. The patent also details the steps for concentrating, purifying, and formulating rASA through a purification process that includes one or more chromatography steps. Additionally, the invention provides a pharmaceutical composition containing rASA, which is efficiently endocytosed via the mannose-6-phosphate receptor pathway in vivo. The second patent reiterates similar processes and applications, emphasizing the potential for reducing galactosyl sulphatide levels in target cells within the peripheral and central nervous systems.

Career Highlights

Pia Hyden is currently associated with Shire Pharmaceuticals Ireland Limited, where she continues to advance her research and innovations. Her work has been pivotal in developing therapeutic solutions for complex medical conditions.

Collaborations

Hyden has collaborated with notable colleagues, including Jens Fogh and Claes Andersson, to further her research and enhance the impact of her inventions.

Conclusion

Pia Hyden's contributions to biotechnology, particularly in the production of recombinant arylsulfatase A, highlight her role as an influential inventor in her field. Her patents not only advance scientific knowledge but also offer potential therapeutic benefits for patients in need.