Company Filing History:
Years Active: 1992-1998
Title: Phyllis L Osheroff: Innovator in Neurobiology
Introduction
Phyllis L Osheroff is a prominent inventor based in Woodside, CA (US). She has made significant contributions to the field of neurobiology, particularly through her innovative research and patents. With a total of 6 patents, her work has had a profound impact on understanding sensory and motor neuron functions.
Latest Patents
One of her latest patents involves the Sensory and Motor Neuron Derived Factor (SMDF). This patent discloses isolated SMDF, isolated DNA encoding SMDF, and recombinant or synthetic methods of preparing SMDF. SMDF contains a β-type EGF-like domain and a unique N-terminal sequence that distinguishes it from all previously reported neuregulins. When expressed in recombinant cell culture, SMDF activates tyrosine phosphorylation of the HER2/neu receptor in human breast cancer cells and exhibits mitogenic activity on Schwann cells. Furthermore, Northern blot and in situ hybridization analyses reveal that SMDF is nervous tissue specific and is highly expressed in the human and rat spinal cord motor neurons and sensory neurons.
Career Highlights
Phyllis L Osheroff has had a distinguished career, working at Genentech, Inc., where she has been able to apply her research in a practical setting. Her innovative work has not only advanced scientific understanding but has also contributed to potential therapeutic applications in medicine.
Collaborations
Throughout her career, she has collaborated with notable professionals, including Michael J Cronin. These collaborations have further enriched her research and expanded the impact of her inventions.
Conclusion
Phyllis L Osheroff is a trailblazer in the field of neurobiology, with her patents paving the way for future research and applications. Her contributions continue to influence the scientific community and hold promise for advancements in medical treatments.