Location History:
- Maurepas, FR (2003)
- Paris, FR (2004 - 2012)
Company Filing History:
9 out of 870 
2 out of 21 
2 out of 5,094 
Years Active: 2003-2012
Title: The Innovator Behind Advanced Bioluminescence Imaging: Philippe Brulet
Introduction
Philippe Brulet, based in Paris, France, is a prominent inventor with a remarkable portfolio of ten patents. His innovative contributions to the fields of neurobiology and imaging are paving the way for groundbreaking research methodologies.
Latest Patents
One of his most significant patents focuses on "Non-invasive real-time in vivo bioluminescence imaging of local Ca²⁺ dynamics in living organisms." This invention details a method that employs optical detection techniques to monitor calcium dynamics in biological systems. By utilizing a recombinant calcium-sensitive polypeptide that incorporates a chemiluminescent protein linked to a fluorescent protein, Brulet's invention allows for precise visualization of calcium concentration in live subjects. The development of transgenic non-human animals that express this recombinant polypeptide further enhances the ability to monitor calcium dynamics in specific tissues or cellular compartments.
Another important patent involves "Methods for direct visualization of active synapses." This entails the use of a biomarker, which includes a fragment of tetanus toxin and a reporter protein, for visualizing active synapses in neuronal cells. Brulet's method not only facilitates the visualization of synapse activity but also aids in the screening of molecules that could modulate synapse functions. Additionally, his work contributes to developing kits aimed at the early diagnosis of neurodegenerative diseases by employing the unique biomarker he has designed.
Career Highlights
Philippe Brulet's career includes significant engagements with prestigious institutions such as the Institut Pasteur and the Centre National de la Recherche Scientifique. His work in these research environments has solidified his reputation as a leading innovator in his field, contributing both to academic knowledge and practical applications.
Collaborations
Throughout his career, Brulet has collaborated with notable colleagues, including Hervé Le Mouellic and Valérie Baubet. These partnerships have further enriched his research and patent developments, illustrating the importance of teamwork in scientific innovation.
Conclusion
Philippe Brulet's inventive spirit and scientific rigor have led to transformative advancements in the study of calcium dynamics and synaptic activity. His patents not only underscore his commitment to research excellence but also demonstrate his ability to apply innovative solutions to complex biological questions. As he continues to contribute to the scientific community, his work will undoubtedly inspire future innovations in the field.