Company Filing History:
Years Active: 2017
Title: The Innovations of Philip Lo Grasso
Introduction
Philip Lo Grasso is an accomplished inventor based in Jupiter, Florida. He has made significant contributions to the field of medical research, particularly in the development of treatments for diseases such as Parkinson's disease and myocardial infarction. His work focuses on kinase inhibitors, which play a crucial role in various medical disorders.
Latest Patents
Lo Grasso holds a patent for "Bidentate-binding modulators of LRRK2 and JNK kinases." This innovative patent addresses the dual inhibition of both JNK and LRRK2, which are associated with Parkinson's disease and other medical conditions. The patent describes a bidentate-binding strategy that effectively utilizes the ATP hinge binding and a unique protein surface site outside of the ATP pocket. Notably, compound 6, a potent JNK3 and modest LRRK2 dual inhibitor, has shown impressive enzyme IC50 values of 12 nM and 99 nM for LRRK2-G2019S, respectively. This compound also demonstrated good cell potency and inhibited LRRK2:G2019S induced mitochondrial dysfunction in SHSY5Y cells.
Career Highlights
Lo Grasso is affiliated with The Scripps Research Institute, where he continues to advance his research in kinase inhibitors. His work has garnered attention for its potential impact on treating serious medical conditions.
Collaborations
One of his notable collaborators is Yangbo Feng, with whom he has worked on various research projects.
Conclusion
Philip Lo Grasso's innovative work in the field of kinase inhibitors highlights his commitment to advancing medical research and developing effective treatments for debilitating diseases. His contributions are paving the way for future breakthroughs in the medical field.