Petr Sedmera

Title: Petr Sedmera: Innovator in Pharmaceutical Chemistry

Introduction

Petr Sedmera is a notable inventor based in Prague, Czech Republic. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the synthesis of analgesic compounds. His work is characterized by innovative processes that enhance the efficiency of drug production.

Latest Patents

Petr Sedmera holds a patent for the "Process for the preparation of 3, 14.beta.-dihydroxy-17-normorphinan." This patent outlines a suitable economic process for synthesizing 3,14.beta.-dihydroxy-17-normorphinan, a key intermediate in the semisynthetic synthesis of Butorphanol, an effective analgesic derived from thebaine. The synthesis involves a two-step N-demethylation and concerted dephenoxylation, utilizing chloroformate and sodium action in liquid ammonia, followed by O-demethylation with a complex of aluminium chloride and dialkylsulfide.

Career Highlights

Petr Sedmera is associated with Galena AS, where he applies his expertise in pharmaceutical processes. His innovative approach has led to advancements in the synthesis of important medicinal compounds. With a focus on efficiency and economic viability, Sedmera's work is paving the way for improved analgesic production.

Collaborations

Petr has collaborated with notable colleagues, including Roman Sobotik and Petr Bulej. These partnerships have fostered a collaborative environment that enhances research and development in pharmaceutical chemistry.

Conclusion

Petr Sedmera's contributions to the field of pharmaceutical chemistry, particularly through his innovative patent, demonstrate his commitment to advancing drug synthesis processes. His work continues to impact the development of effective analgesics, showcasing the importance of innovation in medicine.