Peter Matthew Lengyel

Title: Innovations by Peter Matthew Lengyel

Introduction

Peter Matthew Lengyel is an accomplished inventor based in Brooklyn, NY. He has made significant contributions to the field of genetic engineering, particularly through his innovative work on multifunctional alleles. With a total of 3 patents, his research has the potential to impact various applications in biotechnology and medicine.

Latest Patents

One of Peter's latest patents focuses on multifunctional alleles, which are nucleic acid constructs designed to render modifications to a genome. These modifications include null alleles, conditional alleles, and null alleles that comprise COINs. The multifunctional alleles (MFA) he developed allow for the introduction of an allele that can generate a null allele, a conditional allele, or an allele that is a null allele with an additional COIN. The MFAs consist of pairs of cognate recombinase recognition sites, an actuating sequence, a drug selection cassette, and a nucleotide sequence of interest. Upon the action of a recombinase, a conditional allele with a COIN is formed. Further actions by additional recombinases can create alleles that contain only a COIN or only the actuating sequence in sense orientation.

Career Highlights

Peter currently works at Regeneron Pharmaceuticals, Inc., where he continues to advance his research in genetic modifications. His work is pivotal in developing new methodologies that can enhance genetic engineering techniques.

Collaborations

Peter collaborates with notable colleagues, including Aris N Economides and Andrew J Murphy, who contribute to his innovative projects and research endeavors.

Conclusion

Peter Matthew Lengyel's contributions to the field of genetic engineering through his patents on multifunctional alleles demonstrate his commitment to advancing biotechnology. His work at Regeneron Pharmaceuticals, Inc. positions him as a key figure in the ongoing evolution of genetic research.