Peter J Nicholls

Title: Innovations of Peter J Nicholls

Introduction

Peter J Nicholls is a notable inventor based in Berkshire, GB. He has made significant contributions to the field of cytotoxic reagents, holding a total of 3 patents. His work focuses on developing selective RNase cytotoxic reagents that have the potential to revolutionize treatment methods in medicine.

Latest Patents

One of his latest patents involves a selective cytotoxic RNase reagent. This reagent comprises a toxic moiety that is an RNase linked to a recognition moiety that binds to a specific cell surface marker. The binding of the recognition moiety to a surface marker on a cell allows the toxic moiety to selectively kill the cell. To reduce immunogenicity, the toxic moiety and the recognition moiety of the conjugate are preferably endogenous to the species in which the reagent is intended for use. For cytotoxic reagents intended for use in humans, the toxic moiety is a human ribonuclease, such as angiogenin, while the recognition moiety is a humanized chimeric antibody. The human ribonuclease and chimeric antibody preferably form a fused protein. This invention also relates to pharmaceutical compositions that include the cytotoxic reagent, as well as treatment methods involving its use.

Career Highlights

Peter J Nicholls works for the United States of America as represented by the Department of Health. His innovative work in the field of cytotoxic reagents has garnered attention and respect within the scientific community.

Collaborations

Some of his notable coworkers include Susanna M Rybak and Richard J Youle. Their collaborative efforts contribute to the advancement of research in the field of cytotoxic reagents.

Conclusion

Peter J Nicholls is a distinguished inventor whose work on selective RNase cytotoxic reagents holds promise for future medical applications. His contributions to the field are significant and continue to influence advancements in treatment methods.