Location History:
- Kenosha, WI (US) (1997)
- Westerly, RI (US) (2010 - 2012)
Company Filing History:
Years Active: 1997-2012
Title: Innovations of Peter J Bonk
Introduction
Peter J Bonk is a notable inventor based in Westerly, RI (US). He has made significant contributions to the field of chemistry, particularly in the synthesis of pharmaceutical compounds. With a total of 3 patents, his work has advanced the methodologies used in drug development.
Latest Patents
One of his latest patents is titled "One pot synthesis of tetrazole derivatives of rapamycin." This invention presents a single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on a large scale. The process improves upon currently available synthesis schemes. In this method, dried rapamycin is dissolved in isopropylacetate (IPAc), and the solution is cooled. Following this, 2,6-Lutidine is added, and triflic anhydride is slowly introduced at -30°C. Salts are subsequently removed by filtration. Tetrazole, along with a tert-base diisopropylethylamine (DIEA), is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified using a silica gel column with THF/heptane as the eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product is then dissolved in t-BME and precipitated with heptane. The solids are treated with butylated-hydroxy toluene (BHT) and the solution is concentrated. This process is repeated twice with acetone to remove solvents, and at least one stabilizing agent, such as BHT at 0.5%, is added before drying.
Career Highlights
Peter J Bonk is currently associated with Abbott Laboratories Corporation, where he continues to innovate in the field of pharmaceutical chemistry. His work has been instrumental in developing more efficient synthesis processes that can be applied in large-scale production.
Collaborations
He has collaborated with notable coworkers, including Madhup K Dhaon and Chi-nung Hsiao, contributing to various projects that enhance the capabilities of their research team.
Conclusion
Peter J Bonk's contributions to the field of chemistry, particularly through his innovative patents, have made a significant impact on pharmaceutical synthesis. His work exemplifies the importance of innovation in advancing drug development processes