Peter Hufnagel

Title: Peter Hufnagel and Protein Mixture Analysis by Mass Spectrometry.

Introduction

Peter Hufnagel is an inventor associated with Bremen, Germany, and Bruker Daltonik GmbH. His patent work addresses methods for analyzing complex protein mixtures, including entire proteomes, and detecting previously unknown or unusually expressed proteins.

Latest Patents

The available information identifies one patent associated with Hufnagel: “Protein Mixture Analysis by Mass Spectrometry.” The invention analyzes peptides produced by enzymatic digestion of protein mixtures. It separates the peptides by liquid chromatography and then analyzes the separated fractions, at a different time from the chromatography, using a tandem time-of-flight mass spectrometer with matrix-assisted laser desorption ionization (MALDI).

According to the patent description, this approach can identify many more proteins than commonly used procedures based on two-dimensional gel electrophoresis followed by time-of-flight mass spectrometry. Separating chromatography from mass spectrometry also reduces the time pressure of real-time LC-MS analysis and allows intermediate results to guide measurements toward proteins of interest. Hufnagel’s reported portfolio includes 1 patent.

Career Highlights

Hufnagel’s listed company affiliation is Bruker Daltonik GmbH. His patent highlights work on combining liquid chromatography, enzymatic digestion, and tandem mass spectrometry to improve the analysis of complex protein samples.

Collaborations

Detlev Suckau and Jochen Franzen are identified as Hufnagel’s coworkers. Their names are associated with the collaborative context of his work on protein analysis by mass spectrometry.

Conclusion

Peter Hufnagel’s patent describes a method designed to make complex protein-mixture analysis more efficient and informative by separating peptide chromatography from mass-spectrometric measurement.