Company Filing History:
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1 out of 832,680 Years Active: 1998-2000
Title: The Innovations of Peter Diederik Grootenhuis
Introduction
Peter Diederik Grootenhuis is a notable inventor based in Oss, Netherlands. He has made significant contributions to the field of biochemistry, particularly in the development of glycoprotein hormone structures. With a total of 3 patents, his work has advanced the understanding of hormone interactions at a molecular level.
Latest Patents
Among his latest patents, Grootenhuis has focused on serine protease inhibitors and the three-dimensional representation of glycoprotein hormone structures. His research includes the determination of the three-dimensional structure of human chorionic gonadotrophin (hCG) through X-ray crystallography. The coordinates of individual atoms are presented, allowing for a detailed analysis of the hormone's structure. By utilizing three-dimensional molecular simulation software, Grootenhuis has been able to visualize and compare the original glycoprotein with chemically modified analogues. This innovative approach enables the selection of analogues that maintain the essential spatial arrangement for receptor binding and signal transduction, which are then synthesized and screened for biological activity.
Career Highlights
Grootenhuis has had a distinguished career, working with prominent organizations such as Akzo Nobel N.V. and the University of Glasgow. His expertise in biochemistry and molecular biology has positioned him as a key figure in his field. His patents reflect a deep understanding of molecular interactions and the potential for therapeutic applications.
Collaborations
Throughout his career, Grootenhuis has collaborated with esteemed colleagues, including Neil William Isaacs and Adrian Jonathan Lapthorn. These partnerships have further enriched his research and contributed to the advancement of knowledge in glycoprotein hormones.
Conclusion
Peter Diederik Grootenhuis is a pioneering inventor whose work in glycoprotein hormone structures has made a lasting impact in biochemistry. His innovative patents and collaborations highlight his commitment to advancing scientific understanding and therapeutic possibilities.
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